Geregistreerd op: 16 Jul 2018
|Geplaatst: 04-09-2018 09:31:05 Onderwerp: Don't be afraid to take into consideration
|Mycophenolic acid mycophenolate is an immunosuppressant drug used to prevent rejection in organ transplantation. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability. More recently DaeSean Hamilton Jersey , the salt mycophenolate sodium has also been introduced.
Precautions & Warnings
Administer under the supervision of a health care provider experienced in immunosuppressive therapy and management of organ transplantation and in an equipped facility. Increased risk of lymphoma and increased susceptibility to infection may be related to immunosuppression.
Administration is associated with increased risk of pregnancy loss and congenital malformations. Women of childbearing potential must use contraception.
Perform CBCs weekly during the first month, twice monthly during the second and third months, then monthly through the first year. Monitor patient for signs and symptoms of bacterial, viral Josey Jewell Jersey , or fungal infections, and for signs and symptoms of organ rejection.
No reported cases. At plasma levels >100 mcgml, small amounts of the inactive metabolite may be removed by haemodialysis. Excretion of MPA may be enhanced by bile acid sequestrants (e.g. colestyramine).
Teratogenic in animals; avoid inhalation or direct skin contact. Monitor patients for lymphoproliferative disorders; advise patient to limit exposure to sunlightUV light. Active peptic ulcer disease. Severe renal impairment. Mycophenolate mofetil and mycophenolate sodium are not interchangeable. Perform CBCs; monitor for neutropenia.
Increased plasma levels of both drugs when combined with aciclovir, valaciclovir Isaac Yiadom Jersey , ganciclovir and valganciclovir. Reduced absorption with colestyramine, magnesium- and aluminium hydroxide-containing products, sevelamer and other calcium-free phosphate binders. Reduced plasma levels with ciclosporin, metronidazole Royce Freeman Jersey , quinolones, rifamycins. May reduce plasma levels of progestins; may reduce efficacy of oral contraceptives. Increased plasma levels with probenecid. May reduce efficacy of live vaccines.
mofetil and mycophenolate sodium are not interchangeable. Perform CBCs; monitor for neutropenia.
Food reduces MPA peak serum levels by 40% and 33% following mycophenolate mofetil and mycophenolate sodium admin, respectively. Extent of absorption is not affected. Avoid cat's claw and echinacea as they have immunostimulant effects.
Mycophenolic Acid and Pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Mycophenolic Acid and Lactation
Contraindicated in lactation
Safety and efficacy in cardiac or hepatic transplants not established.
Mycophenolic Acid and Geriatic
Use with caution because of the greater frequency of decreased hepatic, renal Case Keenum Color Rush Jersey , or cardiac function, and concomitant diseases or other drug therapy.
Store at room temperature between 15 to 300c. Protect from heat, light and moisture. Keep away from reach of children.
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